Following the induction of DNA damage, a prominent route of cell inactivation is apoptosis.
During the last ten years, specific DNA lesions that trigger apoptosis have been identified …

Unicellular organisms respond to the presence of DNA lesions by activating cell cycle
checkpoint and repair mechanisms, while multicellular animals have acquired the further …

ATM is one of the sentries at the gate of genome stability. This multifunctional protein kinase
orchestrates the intricate array of cellular responses to DNA double-strand breaks. Absence …

We have generated a mouse model for ataxia-telangiectasia by using gene targeting to
generate mice that do not express the Atm protein. Atm-deficient mice are retarded in …

▪ Abstract Gene mutations provide valuable clues to cellular metabolism. In humans such
insights come mainly from genetic disorders. Ataxia-telangiectasia (AT) and Nijmegen …

Ataxia-telangiectasia (AT) is a complex, autosomal recessive disorder characterized by
cerebellar ataxia, believed to result from progressive neurodegeneration, and …

Ataxia telangiectasia (AT) is a pleiotropic genetic disorder characterized by progressive
neurodegeneration, especially of cerebellar Purkinje cells, immunodeficiency, increased …

Background and purpose: Experimental studies have implicated the normal or 'wild type'p53
protein (ie WTp53) in the cellular response to ionizing radiation and other DNA damaging …

Ionizing radiation triggers diverse responses in human cells encompassing apoptosis,
necrosis, stress-induced premature senescence (SIPS), autophagy, and endopolyploidy (eg …

In rheumatoid arthritis (RA), dysfunctional T cells sustain chronic inflammatory immune
responses in the synovium. Even unprimed T cells are under excessive replication pressure …