Despite being one of the most prevalent tropical diseases, for many years malaria was not a
commercial priority for the pharmaceutical industry. However, in response to the emergence …

Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet,
unfortunately, apart from artemisinin combination therapies there are relatively few effective …

Highlights•Artemisinin is a pro-drug that is activated by heme or iron.•Hemoglobin
degradation generates an artemisinin activator.•Parasite killing requires exposure to an …

Artemisinin (1) is an extract of the Chinese wormwood Artemisia annua and has been used
since ancient times to treat malaria.[1] Today, semisynthetic derivatives artesunate (2) and …

Cyclic peroxides such as the plant-derived 1, 2, 4-trioxane artemisinin and its derivatives are
short-lived, rapidly-acting antimalarials that are now usually combined with standard long …

The present review describes the current status of synthetic five and six-membered cyclic
peroxides such as 1, 2-dioxolanes, 1, 2, 4-trioxolanes (ozonides), 1, 2-dioxanes, 1, 2 …

Malaria disease continues to be a major health problem worldwide due to the emergence of
multidrug-resistant strains of Plasmodium falciparum. In recent days, artemisinin (ART) …

Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …

The isolation of artemisinin from the traditional medicinal herb qīng hāo (Artemisia annua),
its characterization as a peroxide and preparation of the derivatives dihydroartemisinin …