The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

Ventilator-associated pneumonia (VAP) is the most frequent life-threatening nosocomial
infection in intensive care units. The diagnostic is difficult because radiological and clinical …

Background Staphylococcus aureus remains a common cause of ventilator-associated
pneumonia, with little change in incidence over the past 15 years. We aimed to evaluate the …

Antimicrobial de-escalation (ADE) is defined as the discontinuation of one or more
components of combination empirical therapy, and/or the change from a broad-spectrum to …

In a multicenter, observational, propensity-score–weighted cohort of 249 adults with
uncomplicated Pseudomonas aeruginosa bacteremia, patients receiving short-course …

Introduction: Not enough data exist to inform the optimal duration and type of antimicrobial
therapy against GN infections in critically ill patients. Methods: Narrative review based on a …

All medical and surgical specialties depend on the pool of effective antibiotics that continues
to evaporate because of the increasing prevalence of drug-resistant bacteria. Antimicrobial …

Purpose Antibiotic therapy is commonly prescribed longer than recommended in intensive
care patients (ICU). We aimed to provide insight into the decision-making process on …

Since sepsis was first defined, sepsis management has remained challenging. To improve
mortality rates for sepsis and septic shock, an accurate diagnosis and prompt administration …

Background High-level antibiotic consumption plays a critical role in the selection and
spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in …