Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

Organoids form through self-organization processes in which initially homogeneous
populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern …

The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

Tissues take shape through a series of morphogenetic movements guided by local cell-
scale mechanical forces. Current in vitro approaches to recapitulate tissue mechanics rely …

In developing organisms, spatially prescribed cell identities are thought to be determined by
the expression levels of multiple genes. Quantitative tests of this idea, however, require a …

Aberrant epithelial reprogramming can induce metaplastic differentiation at sites of tissue
injury that culminates in transformed barriers composed of scar and metaplastic epithelium …

Trainability, in any substrate, refers to the ability to change future behavior based on past
experiences. An understanding of such capacity within biological cells and tissues would …

Animal development entails the organization of specific cell types in space and time, and
spatial patterns must form in a robust manner. In the zebrafish spinal cord, neural …

Gene expression is inherently noisy, posing a challenge to understanding how precise and
reproducible patterns of gene expression emerge in mammals. Here we investigate this …

In multicellular organisms, secreted ligands selectively activate, or" address," specific target
cell populations to control cell fate decision-making and other processes. Key cell-cell …