Owing to the efficacy in reducing pain and inflammation, non-steroidal anti-inflammatory
drugs (NSAIDs) are amongst the most popularly used medicines confirming their position in …

Certain bacterial pathogens are able to evade the host immune system and persist within
the human host. The consequences of persistent bacterial infections potentially include …

Highly selective and direct electroreductive ring‐opening carboxylation of epoxides with
CO2 in an undivided cell is reported. This reaction shows broad substrate scopes within …

A cell-based phenotypic screen for inhibitors of biofilm formation in mycobacteria identified
the small molecule TCA1, which has bactericidal activity against both drug-susceptible and …

Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

BACKGROUND: Oxygen is both essential and toxic to all forms of aerobic life and the
chemical versatility and reactivity of thiols play a key role in both aspects. Cysteine thiol …

Stochastic formation of Mycobacterium tuberculosis (Mtb) persisters achieves a high level of
antibiotic-tolerance and serves as a source of multidrug-resistant (MDR) mutations. As …

Treatment of tuberculosis (TB) remains challenging, with lengthy treatment durations and
complex drug regimens that are toxic and difficult to administer. Similar to the vast majority of …

Current tuberculosis (TB) drug development efforts are not sufficient to end the global TB
epidemic. Recent efforts have focused on the development of whole-cell screening assays …

Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …