Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited
pathogenic variants in any of 22 FANC genes, which cooperate in the FA/BRCA pathway …

Double strand break (DSB) repair is critical to maintaining the integrity of the genome. DSB
repair deficiency underlies multiple pathologies, including cancer, chromosome instability …

Megaphylls, present in the majority of vascular plants, show in many plant lineages an
abaxial-adaxial polarity in their dorsoventral axis. This polarity commonly translates into …

In acute myeloid leukemia (AML), the restoration of p53 activity through MDM2 inhibition
proved efficacy in combinatorial therapies. WIP1, encoded from PPM1D, is a negative …

Numerous studies have shown that the release of stress hormones resulting from repeated
exposure to chronic psychological stress increases DNA damage and promotes …

When encountering damage, the cells activate the DNA Damage Response (DDR) pathway
and stop the cell cycle until the DNA is repaired. PPM1D/WIP1 phosphatase resumes the …

A proliferating cell must grow, duplicate, and divide. Faithful duplication of DNA is required
to pass the genetic information to the daughter cell. DNA replication is a fundamental …

Fanconi anemia (FA), a chromosome instability syndrome, is caused by inherited
pathogenic variants in any of 22 FANC genes, that cooperate in the FA/BRCA pathway. This …