Reactive oxygen species continuously assault the structure of DNA resulting in oxidation
and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair …

Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

The base excision repair (BER) glycosylase hOGG1 (human oxoguanine glycosylase 1) is
responsible for repairing oxidative lesions in the genome, in particular oxidised guanine …

Atomic force microscopy (AFM) has made significant contributions to the study of protein-
DNA interactions by making it possible to topographically image biological samples. A …

Abstract Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in
DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G· T mispairs …

Base excision repair is the main pathway involved in active DNA demethylation. 5-
formylcytosine and 5-carboxylcytosine, two oxidized moieties of methylated cytosine, are …

Thymine DNA glycosylase (TDG) is a DNA repair enzyme that excises a variety of
mismatched or damaged nucleotides (nts), eg dU, dT, 5fC and 5caC. TDG is shown to play …

Thymine DNA glycosylase (TDG), as a repair enzyme, plays essential roles in maintaining
the genome integrity by correcting several mismatched/damaged nucleobases. TDG …

To decode the function and molecular recognition of several recently discovered cytosine
derivatives in the human genome–5‐hydroxymethylcytosine, 5‐formylcytosine, and 5 …

Human alkyladenine DNA glycosylase (AAG) is a key enzyme that corrects a broad range of
alkylated and deaminated nucleobases to maintain genomic integrity. When encountering …