Gulf War illness: mechanisms underlying brain dysfunction and promising therapeutic strategies
Abstract Gulf War Illness (GWI), a chronic multisymptom health problem, afflicts~ 30% of
veterans served in the first GW. Impaired brain function is among the most significant …
veterans served in the first GW. Impaired brain function is among the most significant …
A review of pre-clinical models for Gulf War Illness
ACR Ribeiro, LS Deshpande - Pharmacology & therapeutics, 2021 - Elsevier
Abstract Gulf War Illness (GWI) is a chronic multisymptomatic disorder that afflicts over 1/3rd
of the 1991 GW veterans. It spans multiple bodily systems and presents itself as a syndrome …
of the 1991 GW veterans. It spans multiple bodily systems and presents itself as a syndrome …
[HTML][HTML] Oral nano-curcumin in a model of chronic Gulf War illness alleviates brain dysfunction with modulation of oxidative stress, mitochondrial function …
Unrelenting cognitive and mood impairments concomitant with incessant oxidative stress
and neuroinflammation are among the significant symptoms of chronic Gulf War Illness …
and neuroinflammation are among the significant symptoms of chronic Gulf War Illness …
Chaperone Sigma1R and antidepressant effect
MV Voronin, YV Vakhitova, SB Seredenin - International Journal of …, 2020 - mdpi.com
This review analyzes the current scientific literature on the role of the Sigma1R chaperone in
the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a …
the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a …
Ketamine Produces Antidepressant Effects by Inhibiting Histone Deacetylases and Upregulating Hippocampal Brain-Derived Neurotrophic Factor Levels in a …
A Ribeiro-Davis, DY Al Saeedy, FM Jahr… - … of Pharmacology and …, 2024 - ASPET
Approximately one-third of Gulf War veterans suffer from Gulf War Illness (GWI), which
encompasses mood disorders and depressive symptoms. Deployment-related exposure to …
encompasses mood disorders and depressive symptoms. Deployment-related exposure to …
GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant‐like effects involving BDNF actions
JE Alvarez‐Contino, E Díaz‐Sánchez… - Journal of Cellular …, 2023 - Wiley Online Library
Dysregulation of adult hippocampal neurogenesis is linked to major depressive disorder
(MDD), with more than 300 million people diagnosed and worsened by the COVID‐19 …
(MDD), with more than 300 million people diagnosed and worsened by the COVID‐19 …
Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans
This article describes the pathophysiology and potential treatments for Gulf War Illness
(GWI), which is a chronic neuropsychiatric illness linked to a combination of chemical …
(GWI), which is a chronic neuropsychiatric illness linked to a combination of chemical …
Epigenetic histone acetylation and Bdnf dysregulation in the hippocampus of rats exposed to repeated, low-dose diisopropylfluorophosphate
ACR Ribeiro, FM Jahr, E Hawkins, MM Kronfol… - Life sciences, 2021 - Elsevier
Aims Deployment-related exposures to organophosphate (OP) compounds are implicated
for Gulf War Illness (GWI) development in First GW veterans. However, reasons for the …
for Gulf War Illness (GWI) development in First GW veterans. However, reasons for the …
Exploring the multifaceted potential of (R)-ketamine beyond antidepressant applications
S Zhang, Y Pu, J Liu, L Li, C An, Y Wu… - Frontiers in …, 2024 - frontiersin.org
(R, S)-and (S)-ketamine have made significant progress in the treatment of treatment-
resistant depression (TRD) and have become a research focus in recent years. However …
resistant depression (TRD) and have become a research focus in recent years. However …
The β-adrenergic receptor blocker and anti-inflammatory drug propranolol mitigates brain cytokine expression in a long-term model of Gulf War Illness
Aims Growing evidence suggests that Gulf War Illness (GWI) is the result of underlying
neuroimmune dysfunction. For example, previously we found that several GWI-relevant …
neuroimmune dysfunction. For example, previously we found that several GWI-relevant …