Iron is an essential dietary element. However, the ability of iron to cycle between oxidized
and reduced forms also renders it capable of contributing to free radical formation, which …

Histone deacetylases (HDACs) are expressed at increased levels in cells of various
malignancies, and the use of HDAC inhibitors has improved outcomes in patients with …

Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …

Simple Summary Breast cancer (BC) is the most common cancer diagnosed among women
worldwide. Despite numerous studies, the pathogenesis of BC is still poorly understood, and …

Quinoline is one of the most important and versatile nitrogen heterocycles embodied in
several biologically active molecules. Within the numerous quinolines developed as …

The histone deacetylases (HDACs) are a superfamily of chromatin-modifying enzymes that
silence transcription through the modification of histones. Among them, HDAC3 is unique in …

Activation of microglia is a common denominator and a pathophysiological hallmark of the
central nervous system (CNS) disorders. Damage or CNS disorders can trigger inflammatory …

The regulation of chromatin by epigenetic mechanisms plays a central role in gene
expression and is essential for development and maintenance of cell identity and function …

Tumor heterogeneity poses one of the greatest challenges to a successful treatment of
cancer. Tumor cell populations consist of different subpopulations that have distinct …

Breast cancer is one of the common malignancies with poor prognosis worldwide. The
treatment of breast cancer patients includes surgery, radiation, hormone therapy …