RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

RNA helicases of the DEAH/RHA family form a large and conserved class of enzymes that
remodel RNA protein complexes (RNPs) by translocating along the RNA. Driven by ATP …

In Alzheimer's disease (AD), spliceosomal proteins with critical roles in RNA processing
aberrantly aggregate and mislocalize to Tau neurofibrillary tangles. We test the hypothesis …

RNA-binding proteins (RBPs) are key players regulating RNA processing and are
associated with disorders ranging from cancer to neurodegeneration. Here, we present a …

Understanding the mechanisms of pre-mRNA splicing is limited by the technical challenges
to examining spliceosomes in vivo. Here, we report the isolation of RNP complexes derived …

Although inhibition of the androgen–androgen receptor (AR) axis effectively represses the
growth of prostate cancer, most of all cases eventually become castration-resistant prostate …

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases, which
significantly impact the quality of life. Transcriptome-wide association study (TWAS) was …

We determined that over 40 spliceosomal proteins are conserved between many fungal
species and humans but were lost during the evolution of S. cerevisiae, an intron-poor yeast …

Triple-negative breast cancer (TNBC), although highly lethal, lacks validated therapeutic
targets. Here, we report that U2 snRNP-associated SURP motif-containing protein …

Fragile X syndrome (FXS) is caused by inactivation of the FMR1 gene and loss of encoded
FMRP, an RNA binding protein that represses translation of some of its target transcripts …