RSV prevention in all infants: which is the most preferable strategy?

S Esposito, B Abu Raya, E Baraldi, K Flanagan… - Frontiers in …, 2022 - frontiersin.org
Respiratory syncytial virus (RSV) causes a spectrum of respiratory illnesses in infants and
young children that may lead to hospitalizations and a substantial number of outpatient …

The therapeutic age of the neonatal Fc receptor

M Pyzik, LK Kozicky, AK Gandhi… - Nature Reviews …, 2023 - nature.com
IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …

The neonatal Fc receptor (FcRn): a misnomer?

M Pyzik, KMK Sand, JJ Hubbard, JT Andersen… - Frontiers in …, 2019 - frontiersin.org
Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

Pharmacokinetics of monoclonal antibodies

JT Ryman, B Meibohm - CPT: pharmacometrics & systems …, 2017 - Wiley Online Library
Monoclonal antibodies (mAbs) have developed in the last two decades into the backbone of
pharmacotherapeutic interventions in a variety of indications, with currently more than 40 …

IgG subclasses and allotypes: from structure to effector functions

G Vidarsson, G Dekkers, T Rispens - Frontiers in immunology, 2014 - frontiersin.org
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …

[HTML][HTML] Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

P Lundquist, P Artursson - Advanced drug delivery reviews, 2016 - Elsevier
In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …

Perspectives on immunoglobulins in colostrum and milk

WL Hurley, PK Theil - Nutrients, 2011 - mdpi.com
Immunoglobulins form an important component of the immunological activity found in milk
and colostrum. They are central to the immunological link that occurs when the mother …

FcRn: the neonatal Fc receptor comes of age

DC Roopenian, S Akilesh - Nature reviews immunology, 2007 - nature.com
The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of
passive humoral immunity from a mother to her fetus. In addition, throughout life, FcRn …

Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances

S Xu, BZ Olenyuk, CT Okamoto… - Advanced drug delivery …, 2013 - Elsevier
Targeting of drugs and their carrier systems by using receptor-mediated endocytotic
pathways was in its nascent stages 25years ago. In the intervening years, an explosion of …

Unraveling the interaction between FcRn and albumin: opportunities for design of albumin-based therapeutics

KMK Sand, M Bern, J Nilsen, HT Noordzij… - Frontiers in …, 2015 - frontiersin.org
The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies
of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for …