Tuning the cytokine responses: an update on interleukin (IL)-4 and IL-13 receptor complexes

IS Junttila - Frontiers in immunology, 2018 - frontiersin.org
Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic
inflammation. They play important roles in regulating the responses of lymphocytes, myeloid …

Engineering the IL‐4/IL‐13 axis for targeted immune modulation

ZJ Bernstein, A Shenoy, A Chen… - Immunological …, 2023 - Wiley Online Library
The structurally and functionally related interleukin‐4 (IL‐4) and IL‐13 cytokines play pivotal
roles in shaping immune activity. The IL‐4/IL‐13 axis is best known for its critical role in T …

Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria

M Gohrbandt, A Lipski, JW Grimshaw… - The EMBO …, 2022 - embopress.org
All living organisms adapt their membrane lipid composition in response to changes in their
environment or diet. These conserved membrane‐adaptive processes have been studied …

Structure of the IFNγ receptor complex guides design of biased agonists

JL Mendoza, NK Escalante, KM Jude… - Nature, 2019 - nature.com
The cytokine interferon-γ (IFNγ) is a central coordinator of innate and adaptive immunity, but
its highly pleiotropic actions have diminished its prospects for use as an immunotherapeutic …

Dynamic plasma membrane organization: a complex symphony

S van Deventer, AB Arp, AB van Spriel - Trends in Cell Biology, 2021 - cell.com
Membrane protein organization is essential for proper cellular functioning and the result of a
dynamic exchange between protein monomers, nanoscale protein clusters, and microscale …

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

A Tsirigotaki, A Dansercoer… - Nature Structural & …, 2023 - nature.com
The adipokine Leptin activates its receptor LEP-R in the hypothalamus to regulate body
weight and exerts additional pleiotropic functions in immunity, fertility and cancer. However …

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

C Gorby, J Sotolongo Bellón, S Wilmes, W Warda… - Science …, 2020 - science.org
Interleukin-10 (IL-10) is a dimeric cytokine with both immunosuppressive and
immunostimulatory activities; however, IL-10–based therapies have shown only marginal …

Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds

H Yang, UY Ulge, A Quijano-Rubio… - Nature chemical …, 2023 - nature.com
Abstract The interleukin-4 (IL-4) cytokine plays a critical role in modulating immune
homeostasis. Although there is great interest in harnessing this cytokine as a therapeutic in …

[HTML][HTML] Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase

V Weissert, B Rieger, S Morris, T Arroum… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Mitochondrial F 1 FO ATP synthase is the key enzyme for mitochondrial bioenergetics.
Dimeric F 1 F O-ATP synthase, is preferentially located at the edges of the cristae and its …

Single molecule analyses reveal dynamics of Salmonella translocated effector proteins in host cell endomembranes

V Göser, N Sander, M Schulte, F Scharte… - Nature …, 2023 - nature.com
The facultative intracellular pathogen Salmonella enterica remodels the host endosomal
system for survival and proliferation inside host cells. Salmonella resides within the …