Highlights•Time-resolved structural information is key to understanding biological mechanism.•The molecular details of biomolecular catalysis and regulation can be studied …
Molecular simulations are a powerful tool to complement and interpret ambiguous experimental data on biomolecules to obtain structural models. Such data-assisted …
JS Hub - Current opinion in structural biology, 2018 - Elsevier
Small-angle and wide-angle X-ray scattering in solution (SAXS, WAXS, SWAXS) is an increasingly accurate method for obtaining information on biomolecular structures …
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer …
K Pounot, G Schirò, M Levantino - Current Opinion in Structural Biology, 2023 - Elsevier
Relevant events during protein function such as ligand binding/release and interaction with substrates or with light are often accompanied by out-of-equilibrium structural dynamics …
Small-angle X-ray scattering is an increasingly popular technique used to detect protein structures and ensembles in solution. However, the refinement of structures and ensembles …
L Dimitrova-Paternoga, PKA Jagtap, PC Chen… - Structure, 2020 - cell.com
Ribonucleoprotein complexes (RNPs) are central to all processes in the cell. One of the prerequisites to understand how RNPs work is to determine their high-resolution structures …
Small-angle X-ray scattering (SAXS) experiments provide low-resolution but valuable information about the dynamics of biomolecular systems, which could be ideally integrated …
P Chen, R Shevchuk, FM Strnad, C Lorenz… - Journal of chemical …, 2019 - ACS Publications
Small-angle X-ray and small-angle neutron scattering (SAXS/SANS) provide unique structural information on biomolecules and their complexes in solution. SANS may provide …