Crk and CrkL adaptor proteins: networks for physiological and pathological signaling
RB Birge, C Kalodimos, F Inagaki, S Tanaka - Cell Communication and …, 2009 - Springer
Abstract The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of
essential signal transduction pathways in humans and other organisms that act as major …
essential signal transduction pathways in humans and other organisms that act as major …
Crk and CrkL as therapeutic targets for cancer treatment
T Park - Cells, 2021 - mdpi.com
Crk and CrkL are cellular counterparts of the viral oncoprotein v-Crk. Crk and CrkL are
overexpressed in many types of human cancer, correlating with poor prognosis …
overexpressed in many types of human cancer, correlating with poor prognosis …
Reciprocal and Complementary Role of MET Amplification and EGFR T790M Mutation in Acquired Resistance to Kinase Inhibitors in Lung Cancer
K Suda, I Murakami, T Katayama, K Tomizawa… - Clinical cancer …, 2010 - AACR
Purpose: In epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy
for lung cancer patients, acquired resistance develops almost inevitably and this limits the …
for lung cancer patients, acquired resistance develops almost inevitably and this limits the …
Activation of abl family kinases in solid tumors
SS Ganguly, R Plattner - Genes & cancer, 2012 - journals.sagepub.com
Although c-Abl and Arg non–receptor tyrosine kinases are well known for driving leukemia
development, their role in solid tumors has not been appreciated until recently …
development, their role in solid tumors has not been appreciated until recently …
Abl kinases regulate HGF/Met signaling required for epithelial cell scattering, tubulogenesis and motility
R Li, JF Knight, M Park, AM Pendergast - PLoS One, 2015 - journals.plos.org
Tight regulation of receptor tyrosine kinases (RTKs) is crucial for normal development and
homeostasis. Dysregulation of RTKs signaling is associated with diverse pathological …
homeostasis. Dysregulation of RTKs signaling is associated with diverse pathological …
PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading
KS Zeller, O Idevall-Hagren, A Stefansson, T Velling… - Cellular signalling, 2010 - Elsevier
Integrin-mediated cell adhesion activates several signaling effectors, including
phosphatidylinositol 3-kinase (PI3K), a central mediator of cell motility and survival. To …
phosphatidylinositol 3-kinase (PI3K), a central mediator of cell motility and survival. To …
Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5 …
D Mokhtari, A Al-Amin, K Turpaev, T Li… - Diabetologia, 2013 - Springer
Aims/hypothesis It is not clear how small tyrosine kinase inhibitors, such as imatinib
mesilate, protect against diabetes and beta cell death. The aim of this study was to …
mesilate, protect against diabetes and beta cell death. The aim of this study was to …
F-actin-binding domain of c-Abl regulates localized phosphorylation of C3G: role of C3G in c-Abl-mediated cell death
A Mitra, V Radha - Oncogene, 2010 - nature.com
The c-Abl tyrosine kinase maintains cellular homeostasis through its ability to regulate
apoptosis and actin dynamics. In vivo, c-Abl activity is stringently regulated and mechanisms …
apoptosis and actin dynamics. In vivo, c-Abl activity is stringently regulated and mechanisms …
Geminin overexpression promotes imatinib sensitive breast cancer: a novel treatment approach for aggressive breast cancers, including a subset of triple negative
Z Blanchard, N Mullins, P Ellipeddi, JM Lage… - PloS one, 2014 - journals.plos.org
Breast cancer is the second leading cause of cancer-related deaths in women. Triple
negative breast cancer (TNBC) is an aggressive subtype that affects 10–25% mostly African …
negative breast cancer (TNBC) is an aggressive subtype that affects 10–25% mostly African …
Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells
Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic and multi-
functional type I cell surface membrane protein, which is known to be phosphorylated by the …
functional type I cell surface membrane protein, which is known to be phosphorylated by the …