Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

Mast cells have mainly been studied in the setting of allergic disease, but the importance of
mast cells for host defence against several pathogens has now been well established. The …

Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown
mechanisms, induce widespread inflammation. We found that a large proportion of primary …

Mast cells, which are granulocytes found in peripheral tissue, play a central role in
inflammatory and immediate allergic reactions. β‐Tryptase is a neutral serine protease and …

Using a combined pharmacological and gene-deletion approach, we have delineated a
novel mechanism of neurokinin-1 (NK-1) receptor-dependent hyperalgesia induced by …