A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine
stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative …

The ability to catalytically cleave protein substrates after synthesis is fundamental for all
forms of life. Accordingly, site-specific proteolysis is one of the most important post …

Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders
caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with …

Mitochondrial dysfunction has been described as an early pathological mechanism
delineating the selective neurodegeneration that occurs in Huntington's disease (HD), a …

Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes
Huntington's disease, a neurodegenerative disease associated with aging and the …

Adaption of a single protein to perform multiple independent functions facilitates functional
plasticity of the proteome allowing a limited number of protein-coding genes to perform a …

Investigations of synaptic transmission and plasticity in mouse models of Huntington's
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …

Huntingtin proteolysis has been implicated in the molecular pathogenesis of Huntington
disease (HD). Despite an intense effort, the identity of the pathogenic smallest N-terminal …