Colibactin: more than a new bacterial toxin
T Faïs, J Delmas, N Barnich, R Bonnet, G Dalmasso - Toxins, 2018 - mdpi.com
Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new
cyclomodulin called colibactin, which is synthetized by the pks genomic island, was …
cyclomodulin called colibactin, which is synthetized by the pks genomic island, was …
Biosynthesis of cyclopropane in natural products
Covering: 2012 to 2021 Cyclopropane attracts wide interests in the fields of synthetic and
pharmaceutical chemistry, and chemical biology because of its unique structural and …
pharmaceutical chemistry, and chemical biology because of its unique structural and …
Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites
Microbiota-derived metabolites that elicit DNA damage can contribute to colorectal cancer
(CRC). However, the full spectrum of genotoxic chemicals produced by indigenous gut …
(CRC). However, the full spectrum of genotoxic chemicals produced by indigenous gut …
Colibactin DNA-damage signature indicates mutational impact in colorectal cancer
PJ Dziubańska-Kusibab, H Berger, F Battistini… - Nature medicine, 2020 - nature.com
The mucosal epithelium is a common target of damage by chronic bacterial infections and
the accompanying toxins, and most cancers originate from this tissue. We investigated …
the accompanying toxins, and most cancers originate from this tissue. We investigated …
Structure elucidation of colibactin and its DNA cross-links
INTRODUCTION Research on the human microbiome has revealed extensive correlations
between bacterial populations and host physiology and disease states. However, moving …
between bacterial populations and host physiology and disease states. However, moving …
The colibactin genotoxin generates DNA interstrand cross-links in infected cells
Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli,
Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island …
Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island …
S-Adenosylmethionine: more than just a methyl donor
Covering: from 2000 up to the very early part of 2023 S-Adenosyl-L-methionine (SAM) is a
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …
Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead
Bacteria of the Burkholderia pseudomallei (BP) group pose a global health threat, causing
the infectious diseases melioidosis, a common cause of pneumonia and sepsis, and …
the infectious diseases melioidosis, a common cause of pneumonia and sepsis, and …
Discovery of the leinamycin family of natural products by mining actinobacterial genomes
Nature's ability to generate diverse natural products from simple building blocks has inspired
combinatorial biosynthesis. The knowledge-based approach to combinatorial biosynthesis …
combinatorial biosynthesis. The knowledge-based approach to combinatorial biosynthesis …
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage
Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the
clb genomic island that has a widespread distribution in pathogenic and commensal human …
clb genomic island that has a widespread distribution in pathogenic and commensal human …