Abstract Lymphocyte activation gene 3 (LAG-3) is an inhibitory receptor that is highly
expressed by exhausted T cells. LAG-3 is a promising immunotherapeutic target, with more …

Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …

Abstract α-Synuclein aggregation is a critical molecular process that underpins the
pathogenesis of Parkinson's disease. Aggregates may originate at synaptic terminals as a …

Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …

Highlights•LAG-3 is a highly important next-generation immune checkpoint molecule.•Ninety-
seven clinical trials are evaluating at least 16 LAG-3-targeting molecules.•Here we identify …

Cognitive impairment occurs in most individuals with Parkinson's disease (PD), exacting a
high toll on patients, their caregivers, and the healthcare system. In this review, we begin by …

The progressive accumulation of insoluble aggregates of the presynaptic protein alpha-
synuclein (α-Syn) is a hallmark of neurodegenerative disorders including Parkinson's …

α-Synuclein (asyn) is a key pathogenetic factor in a group of neurodegenerative diseases
generically known as synucleinopathies, including Parkinson's disease (PD), dementia with …

Many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease,
are characterised by the accumulation of misfolded protein deposits in the brain, leading to a …

Achieving good cell recovery after cryopreservation is an essential process when working
with induced pluripotent stem cells (iPSC). Optimized freezing and thawing methods are …