HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

M Lechner, J Liu, L Masterson, TR Fenton - Nature reviews Clinical …, 2022 - nature.com
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …

Phase II randomized trial of transoral surgery and low-dose intensity modulated radiation therapy in resectable p16+ locally advanced oropharynx cancer: an ECOG …

RL Ferris, Y Flamand, GS Weinstein, S Li… - Journal of clinical …, 2022 - ascopubs.org
PURPOSE Definitive or postoperative chemoradiation (CRT) is curative for human
papillomavirus–associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity …

A review of the 8th edition of the AJCC staging system for oropharyngeal cancer according to HPV status

P Machczyński, E Majchrzak, P Niewinski… - European Archives of …, 2020 - Springer
Background The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has
increased substantially in recent decades, particularly p16-positive human papillomavirus …

A phase 2 trial of alternative volumes of oropharyngeal irradiation for de-intensification (AVOID): omission of the resected primary tumor bed after transoral robotic …

S Swisher-McClure, JN Lukens, C Aggarwal… - International Journal of …, 2020 - Elsevier
Purpose This trial tested the safety and efficacy of a novel, deintensified radiation therapy
(RT) approach after initial surgical resection for patients with human papilloma virus (HPV) …

A systematic review and meta-analysis of margins in transoral surgery for oropharyngeal carcinoma

P Gorphe, C Simon - Oral oncology, 2019 - Elsevier
Background The objective of this study was to conduct a systematic review and meta-
analysis of the incidence of positive surgical margins after transoral surgery for …

Prevalence and distribution of cervical lymph node metastases in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma

L Bauwens, A Baltres, DJ Fiani, P Zrounba… - Radiotherapy and …, 2021 - Elsevier
Objective In oropharyngeal squamous cell carcinoma (OP-SCC), the prevalence and
distribution of clinical and pathological lymph node metastasis in the neck have been …

Prognostic significance of extranodal extension in HPV-mediated oropharyngeal carcinoma: a systematic review and meta-analysis

L Benchetrit, SJ Torabi, B Givi… - … –Head and Neck …, 2021 - journals.sagepub.com
Objective To determine the prognostic role of extranodal extension (ENE) among patients
with human papilloma virus–positive (HPV+) oropharyngeal squamous cell carcinoma …

Increased rate of recurrence and high rate of salvage in patients with human papillomavirus–associated oropharyngeal squamous cell carcinoma with adverse …

RM Carey, D Shimunov, GS Weinstein… - Head & …, 2021 - Wiley Online Library
Background Some patients with human papillomavirus (HPV)–associated oropharyngeal
squamous cell carcinoma (OPSCC) do not receive guideline‐recommended postoperative …

Oropharyngeal squamous cell carcinoma in 390 patients: analysis of clinical and histological criteria which significantly impact outcome

LDR Thompson, R Burchette, S Iganej… - Head and Neck …, 2020 - Springer
This study evaluates the prognostic impact of several factors in oropharyngeal squamous
cell carcinoma (OPSCC), controlling for human papillomavirus (HPV)-associated tumors and …

Oncologic outcomes of human papillomavirus–associated oropharynx carcinoma treated with surgery alone: A 12‐institution study of 344 patients

WR Ryan, MJ Xu, E Ochoa, KA Plonowska‐Hirschfeld… - Cancer, 2021 - Wiley Online Library
Background The oncologic outcomes of surgery alone for patients with American Joint
Committee on Cancer 7th edition (AJCC 7th) pN2a and pN2b human papillomavirus …