Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins
IH Greger, JF Watson, SG Cull-Candy - Neuron, 2017 - cell.com
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
[HTML][HTML] Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis
S Zhang, TN Edwards, VK Chaudhri, J Wu, JA Cohen… - Cell, 2021 - cell.com
Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical
and functional associations with sensory afferent neurons. We reveal that epidermal nerve …
and functional associations with sensory afferent neurons. We reveal that epidermal nerve …
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
The physiology of N-methyl-d-aspartate (NMDA) receptors is fundamental to brain
development and function. NMDA receptors are ionotropic glutamate receptors that function …
development and function. NMDA receptors are ionotropic glutamate receptors that function …
Precision calcium imaging of dense neural populations via a cell-body-targeted calcium indicator
Methods for one-photon fluorescent imaging of calcium dynamics can capture the activity of
hundreds of neurons across large fields of view at a low equipment complexity and cost. In …
hundreds of neurons across large fields of view at a low equipment complexity and cost. In …
Structural mechanism of glutamate receptor activation and desensitization
Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory
synaptic transmission in the vertebrate brain. To gain a better understanding of how …
synaptic transmission in the vertebrate brain. To gain a better understanding of how …
Ligand-gated ion channels: new insights into neurological disorders and ligand recognition
1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
Transsynaptic modulation of kainate receptor functions by C1q-like proteins
K Matsuda, T Budisantoso, N Mitakidis, Y Sugaya… - Neuron, 2016 - cell.com
Postsynaptic kainate-type glutamate receptors (KARs) regulate synaptic network activity
through their slow channel kinetics, most prominently at mossy fiber (MF)-CA3 synapses in …
through their slow channel kinetics, most prominently at mossy fiber (MF)-CA3 synapses in …
Structural basis for integration of GluD receptors within synaptic organizer complexes
J Elegheert, W Kakegawa, JE Clay, NF Shanks… - Science, 2016 - science.org
Ionotropic glutamate receptor (iGluR) family members are integrated into supramolecular
complexes that modulate their location and function at excitatory synapses. However, a lack …
complexes that modulate their location and function at excitatory synapses. However, a lack …
Interacting Glutamate Receptor-Like Proteins in Phloem Regulate Lateral Root Initiation in Arabidopsis
ED Vincill, AE Clarin, JN Molenda, EP Spalding - The Plant Cell, 2013 - academic.oup.com
Molecular, genetic, and electrophysiological evidence indicates that at least one of the plant
Glu receptor-like molecules, GLR3. 4, functions as an amino acid–gated Ca2+ channel at …
Glu receptor-like molecules, GLR3. 4, functions as an amino acid–gated Ca2+ channel at …