Tumor biopsy is often not available or difficult to obtain in patients with solid tumors.
Investigation of the peripheral immune system allows for in-depth and dynamic profiling of …

Frailty is the incremental accumulation of minute defects that progressively impair health and
performance. Frailty is commonly observed in older adults; however, secondary frailty may …

Increased serum advanced glycation end products (AGEs) are commonly found in the
patients with Diabetes mellitus (DM), aging-related diseases, and immune-mediated …

Objective Inflammation is one of the pathogenesis of frailty, Neutrophil to lymphocyte ratio
(NLR) and platelet to lymphocyte ratio (PLR) are newly proposed inflammatory indicators …

Abstract Introduction The IL-12-IFNγ-Th1 and the IL-6-IL-23-Th17 axes are considered the
dominant pathogenic pathways in Giant Cell Arteritis (GCA). Both pathways signal via …

Recent studies have shown that cellular senescence is involved in the pathogenesis of
severe asthma (SA). The objective of this study was to investigate the role of cellular …

In the last few decades, the increasing human life expectancy has led to the inflation of the
elderly population and consequently the escalation of age‐related disorders. Biological …

Background Rheumatoid arthritis is a chronic autoimmune disease. However, the specific
role of senescence in rheumatoid arthritis (RA) is unknown. This study aimed to identify …

Background Observational studies have suggested an association between white blood
cells (WBCs) and frailty, but considering the susceptibility to reverse causality and …

中文摘要背景: 發炎老化反應, 是一種長期低度非感染性的發炎, 此一現象的持續存在對於老化
過程影響甚劇, 並且在老化相關疾病的致病機轉中扮演重要角色. 終期醣化產物是一群由單醣 …