There have been many ups and downs since the introduction of gene therapy as a
therapeutic modality for diseases. However, the journey of gene therapy has reached a …

Immunotherapy has moved to the forefront of modern oncologic treatment in the past few
decades. Various forms of immunotherapy currently are emerging, including oncolytic …

Oncolytic virus therapy is a cancer treatment modality that has the potential to improve
outcomes for patients with currently incurable malignancies. Although intravascular delivery …

Bone loss associated with fracture nonunion, revision total joint arthroplasty (TJA), and
pseudoarthrosis of the spine presents a challenging clinical scenario for the orthopaedic …

Simple Summary Oncolytic virotherapy (OVT) is a promising approach in cancer
immunotherapy. Oncolytic viruses (OVs) could be applied in cancer immunotherapy without …

The adenovirus vector platform remains one of the most efficient toolboxes for generation of
transfer vehicles used in gene therapy and virotherapy to treat tumors, as well as vaccines to …

Gene therapy and vaccine development need more novel adenovirus vectors. Here, we
attempt to provide strategies to construct adenovirus vectors based on restriction-assembly …

Oncolytic viruses (OVs) represent a novel class of cancer immunotherapy agents that
preferentially infect and kill cancer cells and promote protective antitumor immunity …

Simple Summary If harnessed appropriately, oncolytic viruses offer significant potential as
anti-cancer agents. Such virotherapies can be engineered to replicate inside cancerous …

Simple Summary Current cancer therapies are insufficient to cure advanced malignancies
and cause off-target toxicity. Scientists have focused on developing new, more efficacious …