HIV-1 maturation: lessons learned from inhibitors
AB Kleinpeter, EO Freed - Viruses, 2020 - mdpi.com
Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …
effective therapies has accompanied a massive increase in our understanding of the …
Multiple roles of HIV-1 capsid during the virus replication cycle
M Novikova, Y Zhang, EO Freed, K Peng - Virologica Sinica, 2019 - Springer
Human immunodeficiency virus-1 capsid (HIV-1 CA) is involved in different stages of the
viral replication cycle. During virion assembly, CA drives the formation of the hexameric …
viral replication cycle. During virion assembly, CA drives the formation of the hexameric …
A stable immature lattice packages IP6 for HIV capsid maturation
HIV virion assembly begins with the construction of an immature lattice consisting of Gag
hexamers. Upon virion release, protease-mediated Gag cleavage leads to a maturation …
hexamers. Upon virion release, protease-mediated Gag cleavage leads to a maturation …
Crystal structure of an HIV assembly and maturation switch
JM Wagner, KK Zadrozny, J Chrustowicz, MD Purdy… - Elife, 2016 - elifesciences.org
Virus assembly and maturation proceed through the programmed operation of molecular
switches, which trigger both local and global structural rearrangements to produce infectious …
switches, which trigger both local and global structural rearrangements to produce infectious …
Maturation of retroviruses
O Pornillos, BK Ganser-Pornillos - Current opinion in virology, 2019 - Elsevier
During retrovirus maturation, cleavage of the precursor structural Gag polyprotein by the
viral protease induces architectural rearrangement of the virus particle from an immature into …
viral protease induces architectural rearrangement of the virus particle from an immature into …
Structural biology of supramolecular assemblies by magic-angle spinning NMR spectroscopy
CM Quinn, T Polenova - Quarterly reviews of biophysics, 2017 - cambridge.org
In recent years, exciting developments in instrument technology and experimental
methodology have advanced the field of magic-angle spinning (MAS) nuclear magnetic …
methodology have advanced the field of magic-angle spinning (MAS) nuclear magnetic …
High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation
S Mattei, A Tan, B Glass, B Müller… - Proceedings of the …, 2018 - National Acad Sciences
HIV-1 maturation occurs via multiple proteolytic cleavages of the Gag polyprotein, causing
rearrangement of the virus particle required for infectivity. Cleavage results in beta-hairpin …
rearrangement of the virus particle required for infectivity. Cleavage results in beta-hairpin …
CryoET structures of immature HIV Gag reveal six-helix bundle
Gag is the HIV structural precursor protein which is cleaved by viral protease to produce
mature infectious viruses. Gag is a polyprotein composed of MA (matrix), CA (capsid), SP1 …
mature infectious viruses. Gag is a polyprotein composed of MA (matrix), CA (capsid), SP1 …
Quenching protein dynamics interferes with HIV capsid maturation
Maturation of HIV-1 particles encompasses a complex morphological transformation of Gag
via an orchestrated series of proteolytic cleavage events. A longstanding question concerns …
via an orchestrated series of proteolytic cleavage events. A longstanding question concerns …
The effect of inositol hexakisphosphate on HIV-1 particle production and infectivity can be modulated by mutations that affect the stability of the immature Gag lattice
The assembly of an HIV-1 particle begins with the construction of a spherical lattice
composed of hexamer subunits of the Gag polyprotein. The cellular metabolite inositol …
composed of hexamer subunits of the Gag polyprotein. The cellular metabolite inositol …