Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach
Methotrexate (MTX) is a drug which is used to treat different types of cancers but
hepatotoxicity limits its clinical use. Chlorogenic acid (CGA) is one of the most abundant …
hepatotoxicity limits its clinical use. Chlorogenic acid (CGA) is one of the most abundant …
Alleviation of liver dysfunction, oxidative stress and inflammation underlies the protective effect of ferulic acid in methotrexate-induced hepatotoxicity
M Roghani, H Kalantari, MJ Khodayar… - Drug design …, 2020 - Taylor & Francis
Introduction In multiple studies, involvement of oxidative stress in the pathogenesis of
methotrexate (MTX)-mediated liver damage has been confirmed. Use of many drugs has …
methotrexate (MTX)-mediated liver damage has been confirmed. Use of many drugs has …
Effects of resveratrol on methotrexate‐induced testicular damage in rats
This study investigated the probable protective effects of resveratrol (RES), an antioxidant,
against methotrexate‐(MTX‐) induced testis damage. Twenty‐four male Sprague Dawley …
against methotrexate‐(MTX‐) induced testis damage. Twenty‐four male Sprague Dawley …
Hepatoprotective effect of mulberry (Morus nigra) leaves extract against methotrexate induced hepatotoxicity in male albino rat
HM Tag - BMC complementary and alternative medicine, 2015 - Springer
Background Drug-induced liver injury is a major health problem that challenges not only
health care professionals but also the pharmaceutical industry and drug regulatory …
health care professionals but also the pharmaceutical industry and drug regulatory …
[HTML][HTML] Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats
AIM: To investigate the potential role of oxidative stress and the possible therapeutic effects
of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX) …
of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX) …
[HTML][HTML] Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats
AM Fayez, S Zakaria, D Moustafa - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Hepatic injury is a major side effect associated with methotrexate (MTX) therapy resulting
from inflammatory reactions and oxidative stress induction. Therefore, liver fibrosis incidence …
from inflammatory reactions and oxidative stress induction. Therefore, liver fibrosis incidence …
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats
The aim of the current study was to investigate the probable protective effects of
Pentoxifylline (PTX) and Alpha Lipoic Acid (ALA), which display anti-oxidative efficacy …
Pentoxifylline (PTX) and Alpha Lipoic Acid (ALA), which display anti-oxidative efficacy …
Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats
Background Methotrexate (MTX) is used commonly in the treatment of various cancers and
inflammatory diseases; nevertheless, the associated hepatotoxicity has limited its clinical …
inflammatory diseases; nevertheless, the associated hepatotoxicity has limited its clinical …
Protective effects of phloridzin against methotrexate-induced liver toxicity in rats
MMA Khalifa, AG Bakr, AT Osman - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Background Liver is the largest internal organ concerning with metabolism, hormonal
balance and clarifying of the toxins. One of the main complications of methotrexate (MTX) …
balance and clarifying of the toxins. One of the main complications of methotrexate (MTX) …
[HTML][HTML] Ameliorating effects of tempol on methotrexate-induced liver injury in rats
Methotrexate (MTX) is used in the treatment of certain types of cancers and chronic
inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects …
inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects …