As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol
and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of …

Cholesterol homeostasis has been implicated in the regulation of cellular and body
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …

Evidence from preclinical studies suggests that the competitive HMG-CoA reductase
(HMGCR) inhibitors universally known as' statins,'in addition to being powerful drugs that …

Purpose Female breast cancer is the most prevalent cancer worldwide. Emerging evidence
shows that simvastatin (SIM) has promising anticancer activities. However, the underlying …

Atherosclerotic cardiovascular disease (ASCVD) frequently results in sudden death and
poses a serious threat to public health worldwide. The drugs approved for the prevention …

Rescue of cognitive function represents an unmet need in the treatment of
neurodegenerative disorders such as Alzheimer's disease (AD). Nutraceuticals deliver a …

Raloxifene hydrochloride (RLX), an antiosteoporotic agent, has been utilized for guarding
against breast cancer and recently, for the disease management owing to its estrogen …

Breast cancer (BC) remains a significant health burden worldwide, necessitating the
development of innovative therapeutic strategies. The B-cell lymphoma 2 (Bcl-2) family …

Fluvastatin (FLV) is a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor
often used to lower total and low-density lipoprotein (LDL) cholesterol and for the prevention …

Vinpocetine (VNP), a semisynthetic active pharmaceutical ingredient, is used for oral
management of cerebrovascular diseases because of its ability to enhance the blood flow to …