Epidemiology of the idiopathic inflammatory myopathies

T Khoo, JB Lilleker, BYH Thong, V Leclair… - Nature Reviews …, 2023 - nature.com
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of systemic
autoimmune diseases that affect the skeletal muscles and can also involve the skin, joints …

Neurological adverse events of immune checkpoint inhibitors: an update of clinical presentations, diagnosis, and management

A Farina, M Villagrán-García, J Honnorat - Revue Neurologique, 2023 - Elsevier
The use of immune checkpoint inhibitors (ICIs) has represented a major advance in cancer
treatment. By enhancing endogenous immune responses to destroy cancer cells, ICIs can …

Management of toxicities from immunotherapy: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up☆

J Haanen, M Obeid, L Spain, F Carbonnel… - Annals of …, 2022 - annalsofoncology.org
Adverse events (AEs) related to the use of immune checkpoint inhibitor (ICI) therapy are
defined as immune-related (IR) AEs (irAEs). irAEs are graded according to the Common …

Neurological outcomes in immune checkpoint inhibitor-related neurotoxicity

A Farina, C Birzu, MH Elsensohn, A Picca… - Brain …, 2023 - academic.oup.com
While the spectrum of neurological immune checkpoint inhibitor-related adverse events is
expanding, patients' outcomes are not well documented. This study aimed to assess …

Autoantibody profiles in patients with immune checkpoint inhibitor-induced neurological immune related adverse events

L Müller-Jensen, S Knauss, L Ginesta Roque… - Frontiers in …, 2023 - frontiersin.org
Background Neurological immune-related adverse events (irAE-n) are severe and
potentially fatal toxicities of immune checkpoint inhibitors (ICI). To date, the clinical …

IFNγ causes mitochondrial dysfunction and oxidative stress in myositis

C Abad, I Pinal-Fernandez, C Guillou… - Nature …, 2024 - nature.com
Idiopathic inflammatory myopathies (IIMs) are severe autoimmune diseases with poorly
understood pathogenesis and unmet medical needs. Here, we examine the role of interferon …

Neurological adverse events of immune checkpoint inhibitors and the development of paraneoplastic neurological syndromes

A Farina, M Villagrán-García, A Vogrig… - The Lancet …, 2024 - thelancet.com
Immune checkpoint inhibitors, a class of oncological treatments that enhance antitumour
immunity, can trigger neurological adverse events closely resembling paraneoplastic …

Imaging assessment of toxicity related to immune checkpoint inhibitors

AM Berz, S Boughdad, N Vietti-Violi, A Digklia… - Frontiers in …, 2023 - frontiersin.org
In recent years, a wide range of cancer immunotherapies have been developed and have
become increasingly important in cancer treatment across multiple oncologic diseases. In …

Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor induced myositis

I Pinal-Fernandez, A Quintana, JC Milisenda… - Annals of the …, 2023 - ard.bmj.com
Objectives Inflammatory myopathy or myositis is a heterogeneous family of immune-
mediated diseases including dermatomyositis (DM), antisynthetase syndrome (AS), immune …

How to diagnose and manage neurological toxicities of immune checkpoint inhibitors: an update

A Vogrig, S Muñiz-Castrillo, A Farina, J Honnorat… - Journal of …, 2022 - Springer
As the use of cancer immunotherapy with immune checkpoint inhibitors (ICIs) is expanding
rapidly for the treatment of many tumor types, it is crucial that both neurologists and …