No inkling has been found of what happens in a cell when it becomes neoplastic, and how
this state of affairs is passed on when it multiplies. A favorite explanation has been that …

Polycyclic aromatic hydrocarbons are ubiquitous contaminants in the environment. Benzo [a]
pyrene (BaP), a prototypical member of this class of chemicals, has been extensively studied …

The effect of mammary gland-specific expression of the polyomavirus middle T antigen was
examined by establishing lines of transgenic mice that carry the middle T oncogene under …

We have used transgenic mice that carry an activated c-neu oncogene driven by a mouse
mammary tumor virus (MMTV) promoter to assess the stepwise progression of …

We have produced 13 strains of transgenic mice that carry an otherwise normal mouse myc
gene in which increasingly larger portions of the myc promoter region have been replaced …

We have derived and mated separate strains of transgenie mice that carry either the v-Ha-
ras or the c-myc gene driven by the mouse mammary tumor virus (MMTV) …

We have devised a sensitive means to assess the antitumor effect of cytokines that act via
the mobilization of host-mediated defenses. This assay involves transfecting malignant cells …

A. Theoretical considerations. 208 B. Reactive intermediates and mutagenesis 208 C.
Reactive intermediates and malignant transformation. 209 D. Correlations among …

An infectious retrovirus vector has been used to transfer a bacterial gene encoding
resistance to the neomycin analogue G418 into pluripotent haematopoietic stem cells …

Glucocorticoids stimulate transcriptional initiation within integrated mammary tumor virus
(MTV) DNA sequences in infected cells. We report here that production of herpes simplex …