Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all
organisms, and provides the reducing power for anabolic reactions and redox balance …

Background Colorectal carcinoma (CRC) is one of the most common malignant tumors, and
its main cause of death is tumor metastasis. RNA N 6-methyladenosine (m 6 A) is an …

Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

Ferroptosis has been linked to the pathogenesis of hepatic injury induced by
ischemia/reperfusion (I/R). However, the mechanistic basis remains unclear. In this study, by …

Although glucose, through pentose phosphate pathway (PPP), is the main source to
generate NADPH, solid tumors are often deprived of glucose, hence alternative metabolic …

Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading
malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little …

Tumor cells often reprogram their metabolism for rapid proliferation. The roles of long
noncoding RNAs (lncRNAs) in metabolism remodeling and the underlying mechanisms …

The tricarboxylic acid (TCA) cycle is the main source of cellular energy and participates in
many metabolic pathways in cells. Recent reports indicate that dysfunction of TCA cycle …