Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes

Y Demir, H Ceylan, C Türkeş… - Journal of Biomolecular …, 2022 - Taylor & Francis
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …

Effects of valsartan combined with α-lipoic acid on renal function in patients with diabetic nephropathy: a systematic review and meta-analysis

F Sun, D Jiang, J Cai - BMC endocrine disorders, 2021 - Springer
Background Diabetic nephropathy (DN) is one of the most serious microvascular
complications of diabetes, valsartan and α-lipoic acid alone or in combination has been …

Thermogenic adipose redox mechanisms: potential targets for metabolic disease therapies

AK Putman, GA Contreras, EP Mottillo - Antioxidants, 2023 - mdpi.com
Metabolic diseases, such as diabetes and non-alcoholic fatty liver disease (NAFLD), have
several negative health outcomes on affected humans. Dysregulated energy metabolism is …

Relationship between diabetic nephropathy and development of diabetic macular edema in addition to diabetic retinopathy

Y Suzuki, M Kiyosawa - Biomedicines, 2023 - mdpi.com
This study aimed to examine the relationship between diabetic retinopathy (DR) and
systemic factors. We evaluated 261 patients (143 men, 118 women, aged 70.1±10.1 years) …

Long noncoding RNA growth arrest‐specific transcript 5 alleviates renal fibrosis in diabetic nephropathy by downregulating matrix metalloproteinase 9 through …

L Zhang, S Zhao, Y Zhu - The FASEB Journal, 2020 - Wiley Online Library
Diabetic nephropathy (DN) is a frequently occurred microvascular complication associated
with type I and type II diabetes mellitus. The participation of long noncoding RNAs (lncRNAs) …

醋酸泼尼松对糖尿病肾病模型大鼠肾功能, 肾脏炎性反应及AMPK/SIRT1 信号通路的影响

邓九红, 郑超, 王声遥, 王心怡 - 基础医学与临床, 2022 - journal11.magtechjournal.com
目的探究醋酸泼尼松对糖尿病肾病(DN) 大鼠肾脏炎性反应及腺苷酸活化蛋白激酶(AMPK)/沉默
信息调节因子1 (SIRT1) 信号通路的影响. 方法随机选取12 只大鼠作为对照组 …

Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro

Q Huang, Y Zhang, Y Jiang, L Huang, LIU Qiong… - Chinese Journal of …, 2023 - Elsevier
Lignans derived from Eucommia ulmoides Oliver (Eucommia lignans) inhibit the progression
of inflammatory diseases, while their effect on the progression of diabetic nephropathy (DN) …

RPS4Y1 promotes high glucose-induced endothelial cell apoptosis and inflammation by activation of the p38 MAPK signaling

Y Chen, Y Chen, C Tang, Q Zhao, T Xu… - Diabetes, Metabolic …, 2021 - Taylor & Francis
Aim Endothelial dysfunction is a key pathological basis for diabetes mellitus complications,
including diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. This …

Exosomes as promising nanostructures in diabetes mellitus: from insulin sensitivity to ameliorating diabetic complications

M Ashrafizadeh, AP Kumar, AR Aref… - International journal …, 2022 - Taylor & Francis
Diabetes mellitus (DM) is among the chronic metabolic disorders that its incidence rate has
shown an increase in developed and wealthy countries due to lifestyle and obesity. The …

Antidiabetic Effects and Mechanisms of Rosemary (Rosmarinus officinalis L.) and its Phenolic Components

TQ Bao, Y Li, C Qu, ZG Zheng, H Yang… - The American journal of …, 2020 - World Scientific
Diabetes mellitus is a chronic endocrine disease result from absolute or relative insulin
secretion deficiency, insulin resistance, or both, and has become a major and growing …