HPV post-infection microenvironment and cervical cancer

Y Yuan, X Cai, F Shen, F Ma - Cancer Letters, 2021 - Elsevier
Human papillomavirus (HPV) is the most common sexually transmitted virus worldwide.
More than 99% of cervical cancer cases are associated with certain types of HPVs, termed …

The precision prevention and therapy of HPV‐related cervical cancer: new concepts and clinical implications

Z Hu, D Ma - Cancer medicine, 2018 - Wiley Online Library
Cervical cancer is the third most common cancer in women worldwide, with concepts and
knowledge about its prevention and treatment evolving rapidly. Human papillomavirus …

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

CS Eberhardt, HT Kissick, MR Patel, MA Cardenas… - Nature, 2021 - nature.com
T cells are important in tumour immunity but a better understanding is needed of the
differentiation of antigen-specific T cells in human cancer,. Here we studied CD8 T cells in …

Defining HPV-specific B cell responses in patients with head and neck cancer

A Wieland, MR Patel, MA Cardenas, CS Eberhardt… - Nature, 2021 - nature.com
Tumours often contain B cells and plasma cells but the antigen specificity of these
intratumoral B cells is not well understood,,,,,,–. Here we show that human papillomavirus …

Heterogeneity of the head and neck squamous cell carcinoma immune landscape and its impact on immunotherapy

M Canning, G Guo, M Yu, C Myint… - Frontiers in cell and …, 2019 - frontiersin.org
Head and neck squamous cell carcinomas (HNSCCs) are highly aggressive, multi-factorial
tumors in the upper aerodigestive tract affecting more than half a million patients worldwide …

The HPV E6/E7 oncogenes: key factors for viral carcinogenesis and therapeutic targets

K Hoppe-Seyler, F Bossler, JA Braun, AL Herrmann… - Trends in …, 2018 - cell.com
Human papillomavirus (HPV)-induced cancers are expected to remain a major health
problem worldwide for decades. The growth of HPV-positive cancer cells depends on the …

Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression

R Saleh, E Elkord - Seminars in cancer biology, 2020 - Elsevier
In the tumor microenvironment (TME), tumor cells are constantly evolving to reduce
neoantigen generation and the mutational burden to escape the anti-tumor response. This …

Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk

RV Hewavisenti, J Arena, CL Ahlenstiel… - Frontiers in …, 2023 - frontiersin.org
Human papillomavirus (HPV), a common sexually transmitted virus infecting mucosal or
cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide …

[HTML][HTML] Therapeutic vaccines for high-risk HPV-associated diseases

A Chabeda, RJR Yanez, R Lamprecht, AE Meyers… - Papillomavirus …, 2018 - Elsevier
Cancer is the second leading cause of death worldwide, and it is estimated that Human
papillomavirus (HPV) related cancers account for 5% of all human cancers. Current HPV …

[HTML][HTML] The emerging role of immunotherapy in head and neck squamous cell carcinoma (HNSCC): anti-tumor immunity and clinical applications

P Economopoulou, C Perisanidis… - Annals of …, 2016 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma (HNSCC) carries a poor prognosis, with low
survival rates for advanced stage tumors and minimal improvement in survival trends …