Medicinal chemistry strategies targeting PRMT5 for cancer therapy

S Fu, Q Zheng, D Zhang, C Lin, L Ouyang… - European Journal of …, 2022 - Elsevier
Abstract Protein arginine methyltransferases 5 (PRMT5), a therapeutic target whose main
physiological function is mono-and symmetric dimethylation of arginine, has drawn …

Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation

Z Yang, F Xu, AE Teschendorff, Y Zhao… - Frontiers in molecular …, 2022 - frontiersin.org
DNA methylation is one of the most important epigenetic mechanisms that governing
regulation of gene expression, aberrant DNA methylation patterns are strongly associated …

[HTML][HTML] Comprehensive landscape of epigenetic-dysregulated lncRNAs reveals a profound role of enhancers in carcinogenesis in BC subtypes

H Zhao, X Liu, L Yu, S Lin, C Zhang, H Xu… - … Therapy-Nucleic Acids, 2021 - cell.com
Aberrant expression of long non-coding RNAs (lncRNA) is associated with altered DNA
methylation and histone modifications during carcinogenesis. However, identifying …

LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations

Y Li, L Li, Z Wang, T Pan, N Sahni, X Jin… - Nucleic acids …, 2018 - academic.oup.com
Gene regulatory network perturbations contribute to the development and progression of
cancer, however, molecular determinants that mediate transcriptional perturbations remain a …

Systematic analysis of DNA methylation-mediated TF dysregulation on lncRNAs reveals critical roles in tumor immunity

J Yin, N Ding, J Yu, Z Wang, L Fu, Y Li, X Li… - … Therapy-Nucleic Acids, 2023 - cell.com
Emerging evidence suggests that DNA methylation affects transcriptional regulation and
expression perturbations of long non-coding RNAs (lncRNAs) in cancer. However, a …

[PDF][PDF] Retracted article: Long non-coding RNA LINC00968 reduces cell proliferation and migration and angiogenesis in breast cancer through up-regulation of …

X Sun, T Huang, C Zhang, S Zhang, Y Wang, Q Zhang… - Cell Cycle, 2019 - Taylor & Francis
Statement of Retraction We, the Editors and Publisher of the journal Cell Cycle, have
retracted the following article Xianfu Sun, Tao Huang, Chengjuan Zhang, Shengze Zhang …

Long non-coding RNA NEAT1 promotes the proliferation, migration, and metastasis of human breast-cancer cells by inhibiting miR-146b-5p expression

S Li, J Hao, Y Hong, J Mai, W Huang - Cancer management and …, 2020 - Taylor & Francis
Background Breast cancer (BC) is the most commonly diagnosed cancer in women. Tumor
recurrence and metastasis are the key causes of death in BC patients. Long non-coding …

Methylation-regulated long non-coding RNA expression in ulcerative colitis

CG Fenton, MK Ray, W Meng, RH Paulssen - International Journal of …, 2023 - mdpi.com
Long non-coding RNAs (lncRNAs) have been shown to play a role in the pathogenesis of
ulcerative colitis (UC). Although epigenetic processes such as DNA methylation and lncRNA …

Systematic review regulatory principles of non-coding RNAs in cardiovascular diseases

Y Li, C Huo, T Pan, L Li, X Jin, X Lin… - Briefings in …, 2019 - academic.oup.com
Cardiovascular diseases (CVDs) continue to be a major cause of morbidity and mortality,
and non-coding RNAs (ncRNAs) play critical roles in CVDs. With the recent emergence of …

Blocking circ_0000520 suppressed breast cancer cell growth, migration and invasion partially via miR-1296/SP1 Axis both in vitro and in vivo

H Zang, Y Li, X Zhang, G Huang - Cancer management and …, 2020 - Taylor & Francis
Background Breast cancer (BCa) is an overwhelming malignant tumor mainly in women
globally. Circular RNAs (circRNAs) are a special type of noncoding RNAs involved in …