Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Targeting of drugs and their carrier systems by using receptor-mediated endocytotic
pathways was in its nascent stages 25years ago. In the intervening years, an explosion of …

Caveolae are a highly abundant but enigmatic feature of mammalian cells. They form
remarkably stable membrane domains at the plasma membrane but can also function as …

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids
that are involved in the lateral compartmentalization of molecules at the cell surface …

Caveolin-1 functions as a membrane adaptor to link the integrin α subunit to the tyrosine
kinase Fyn. Upon integrin ligation, Fyn is activated and binds, via its SH3 domain, to Shc …

Introduction• Cavolae on the plasma membrane• Internalization of caveolae‐Are caveolae
stable, immobile invaginations at the plasma membrane?‐Caveolar budding and pinching …

Yeaman, Charles, Kent K. Grindstaff, and W. James Nelson. New Perspectives on
Mechanisms Involved in Generating Epithelial Cell Polarity. Physiol. Rev. 79: 73–98, 1999 …