Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

The publication of the Clinical Randomization of an Antifibrinolytic in Significant
Hemorrhage-2 (CRASH-2) study and its intense dissemination prompted a renaissance for …

Importance In-hospital administration of tranexamic acid after injury improves outcomes in
patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic …

Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after
traumatic brain injury (TBI) for which no medical treatment is available. Delayed bleeding is …

BACKGROUND This study tested the hypothesis that early routine use of tranexamic acid
(TXA) reduces mortality in a subset of the most critically injured trauma intensive care unit …

Introduction To investigate the mechanism of action of tranexamic acid (TXA) in bleeding
trauma patients, we examined the timing of its effect on mortality. We hypothesised that if …

BACKGROUND Thromboelastography (TEG) on hospital admission can identify
hypercoagulable trauma patients at risk for venous thromboembolism (VTE), but the value of …

BACKGROUND Hemorrhage remains the leading cause of preventable trauma-associated
mortality. Interventions that improve prehospital hemorrhage control and resuscitation are …

Trauma is a leading cause of death in pediatrics. Currently, no medical treatment exists to
reduce mortality in the setting of pediatric trauma; however, this evidence does exist in …

Many trauma systems are examining whether to implement prehospital tranexamic acid
(TXA) protocols since hemorrhage remains the leading cause of potentially preventable …