High frequency oscillations (HFO) have a variety of characteristics: band-limited or broad-
band, transient burst-like phenomenon or steady-state. HFOs may be encountered under …

The generation of interictal epileptiform discharges (IEDs) in partial epilepsies is commonly
ascribed to enhanced excitatory interactions within glutamatergic neuronal networks. Recent …

The mechanisms involved in the transition to an epileptic seizure remain unclear. To
examine them, we used tissue slices from human subjects with mesial temporal lobe …

Secondary generalized seizure (sGS) is a major source of disability in temporal lobe
epilepsy (TLE) with unclear cellular/circuit mechanisms. Here we found that clinical TLE …

Brain electrical activity is largely composed of oscillations at characteristic frequencies.
These rhythms are hierarchically organized and are thought to perform important …

Endocannabinoid signaling is a key regulator of synaptic neurotransmission throughout the
brain. Compelling evidence shows that its perturbation leads to development of epileptic …

Epileptic cortex is characterized by paroxysmal electrical discharges. Analysis of these
interictal discharges typically manifests as spike–wave complexes on …

How the brain encodes the semantic concepts represented by words is a fundamental
question in cognitive neuroscience. Hemodynamic neuroimaging studies have robustly …

Surgical removal of the epileptogenic zone provides an effective therapy for several focal
epileptic syndromes. This surgery offers the opportunity to study pathological activity in living …

With their 'all-or-none'action potential responses, single neurons (or units) are accepted as
the basic computational unit of the brain. There is extensive animal literature to support the …