Ectonucleotidases are key for purinergic signaling. They control the duration of activity of
purinergic receptor agonists. At the same time, they produce hydrolysis products as …

Heterocycles are among the well-established classes of compounds, constituting a wide
range of organic molecules. These structural motifs not only have a dominant presence in a …

Heterocycles are a class of compounds that have been found to be potent inhibitors of
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …

Ectonucleotidase inhibitors are a family of pharmacological drugs that, by selectively
targeting ectonucleotidases, are essential in altering purinergic signaling pathways. The …

Heterocycles, heteroaromatics and spirocyclic entities are ubiquitous components of a wide
plethora of synthetic drugs, biologically active natural products, marketed pharmaceuticals …

The ATP-adenosine pathway has been recently identified as an attractive immune-oncology
target and several drug candidates have been entered clinic trials. Inspired by the report of …

Global people are suffering from the legion of diseases. Cytotoxic property of the chemical
compound would not solely influence effective drug properties and reduce unnecessary side …

Alkaline phosphatases are homodimeric protein enzymes which removes phosphates from
several types of molecules. These catalyze the hydrolysis of monoesters in phosphoric acid …

Nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) catalyzes the hydrolysis of
extracellular nucleotides. It is expressed by immune cells and some carcinomas, eg of …

In this study, we have discovered small druglike molecules as selective inhibitors of human
tissue-nonspecific alkaline phosphatase (h-TNAP), an enzyme critical for the regulation of …