▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

▪ Abstract The neurons of the cochlear ganglion transmit acoustic information between the
inner ear and the brain. These placodally derived neurons must produce a topographically …

Since its discovery over three decades ago, platelet-derived growth factor (PDGF) has been
a model system for learning how growth factors regulate biological processes. For the first …

In mammals, the initial bridge between the physical world of sound and perception of that
sound is established by neurons of the spiral ganglion. The cell bodies of these neurons …

The spectrum of potential biological roles for neurotrophic factors in development and
maturation of the nervous system continues to widen. Careful analysis of the phenotypes of …

The inner ear is a complex sensory organ responsible for balance and sound detection in
vertebrates. It originates from a transient embryonic structure, the otic vesicle, that contains …

Previous work suggested qualitatively different effects of neurotrophin 3 (NT-3) in cochlear
innervation patterning in different null mutants. We now show that all NT-3 null mutants have …

BETA2/NeuroD1 is a bHLH transcription factor that is expressed during development in the
mammalian pancreas and in many locations in the central and peripheral nervous systems …

Binding of target-derived neurotrophins to Trk receptors at nerve terminals is required to
stimulate neuronal survival, differentiation, innervation and synaptic plasticity. The distance …

Destruction of auditory hair cells results in a subsequent loss of auditory neurons. In situ
hybridization and neuronal cell culture studies as well as analyses of the inner ears of …