Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon
A Zakeri, MAJ Kouhbanani… - Nano reviews & …, 2018 - Taylor & Francis
The meaning of gene therapy is the delivery of DNA or RNA to cells for the treatment or
prevention of genetic disorders. The success rate of gene therapy depends on the …
prevention of genetic disorders. The success rate of gene therapy depends on the …
Recent progress and applications of gold nanotechnology in medical biophysics using artificial intelligence and mathematical modeling
JA Moore, JCL Chow - Nano Express, 2021 - iopscience.iop.org
In this topical review, we will explore and challenge how artificial intelligence (AI) and
mathematical modeling apply towards the future in medical applications, focusing on their …
mathematical modeling apply towards the future in medical applications, focusing on their …
Nanocomplex‐mediated in vivo programming to chimeric antigen receptor‐M1 macrophages for cancer therapy
Chimeric antigen receptor‐T (CAR‐T) cell immunotherapy has shown impressive clinical
outcomes for hematologic malignancies. However, its broader applications are challenged …
outcomes for hematologic malignancies. However, its broader applications are challenged …
Unlocking the potential of TRPV1 based siRNA therapeutics for the treatment of chemotherapy-induced neuropathic pain
Chemotherapy-induced neuropathic pain (CINP) is among the most common clinical
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …
Non-viral vectors for delivery of nucleic acid therapies for cancer
The research and development of non-viral gene therapy has been extensive over the past
decade and has received a big push thanks to the recent successful approval of non-viral …
decade and has received a big push thanks to the recent successful approval of non-viral …
One Endothelium-Targeted Combined Nucleic Acid Delivery System for Myocardial Infarction Therapy
Y Shao, C Xu, S Zhu, J Wu, C Sun, S Huang, G Li… - ACS …, 2024 - ACS Publications
Acute myocardial infarction (MI) and ischemic heart disease are the leading causes of heart
failure and mortality. Currently, research on MI treatment is focused on angiogenic and anti …
failure and mortality. Currently, research on MI treatment is focused on angiogenic and anti …
Synthesis of an ethyleneimine/tetrahedral DNA nanostructure complex and its potential application as a multi-functional delivery vehicle
Nowadays, DNA nanostructures are extensively researched for their biocompatibility,
editable functionality, and structural stability. Tetrahedral DNA nanostructures (TDNs) …
editable functionality, and structural stability. Tetrahedral DNA nanostructures (TDNs) …
Delivery of antisense oligonucleotides using multi-layer coated gold nanoparticles to methicillin-resistant S. aureus for combinatorial treatment
The spread of multidrug-resistant (MDR) bacterial infections has become a serious global
threat. We introduce multi-layer coated gold nanoparticles (MLGNPs) delivering antisense …
threat. We introduce multi-layer coated gold nanoparticles (MLGNPs) delivering antisense …
Effect of the protonation level and ionic strength on the structure of linear polyethyleneimine
CE Gallops, C Yu, JD Ziebarth, Y Wang - Acs Omega, 2019 - ACS Publications
Polyethylenimine (PEI) is a highly studied vector for nonviral gene delivery, with a high
transfection efficiency that has been linked with its pH responsiveness. Atomistic molecular …
transfection efficiency that has been linked with its pH responsiveness. Atomistic molecular …
A Lung-Expressing mRNA Delivery Platform with Tunable Activity in Hypoxic Environments
Messenger RNA (mRNA) delivery platforms often facilitate protein expression in the liver
following intravenous injection and have been optimized for use in normally oxygenated …
following intravenous injection and have been optimized for use in normally oxygenated …