The Hippo pathway is generally understood to inhibit tumor growth by phosphorylating the
transcriptional cofactor YAP to sequester it to the cytoplasm and reduce the formation of YAP …

Advances in chromatin mapping have exposed the complex chromatin hierarchical
organization in mammals, including topologically associating domains (TADs) and their …

Complex disease phenotypes often span multiple molecular processes. Functional
characterization of these processes can shed light on disease mechanisms and drug effects …

The DNA damage response (DDR) entails reorganization of proteins and protein complexes
involved in DNA repair. The coordinated regulation of these proteomic changes maintains …

This study describes the identification and target deconvolution of small molecule inhibitors
of oncogenic Yes-associated protein (YAP1)/TAZ activity with potent anti-tumor activity in …

YAP is a central player in cancer development with functions extending beyond its
recognized role in cell growth regulation. Recent work has identified a link between …

Purpose Chemoresistance remains a major challenge in treating pancreatic ductal
adenocarcinoma (PDAC). Although chemoradiation has proven effective in other tumor …

Introduction: Transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo signaling
pathway effector, maintains the balance of cell proliferation, differentiation, and death …

The deregulation of complex diseases often spans multiple molecular processes. A
multimodal functional characterization of these processes can shed light on the disease …

TEAD proteins are the main transcriptional effectors of the Hippo signaling pathway and a
pharmacological target in oncology. Most TEAD-targeting small molecules act by disrupting …