Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

Amphetamine was discovered over 100 years ago. Since then, it has transformed from a
drug that was freely available without prescription as a panacea for a broad range of …

Importance Multiple lines of evidence suggest a deficit in dopamine release in the prefrontal
cortex (PFC) in schizophrenia. Despite the prevalence of the concept of prefrontal cortical …

Cognitive abnormalities are common in Parkinson's disease, with important social and
economic implications. Factors influencing their evolution remain unclear but are crucial to …

This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

The currently dominant neuro-cognitive model of Attention Deficit Hyperactivity Disorder
(AD/HD) presents the condition as executive dysfunction (EDF) underpinned by …

The prefrontal cortex in rats can be distinguished anatomically from other frontal cortical
areas both in terms of cytoarchitectonic characteristics and neural connectivity, and it can be …

• Genetic and environmental influences modulating risk of substance use disorders change
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …

Monamines subserve many critical roles in the brain, and monoaminergic drugs such as
amphetamine have a long history in the treatment of neuropsychiatric disorders and also as …

Cognitive abilities such as working memory (WM) capacity decrease with age. To determine
the neurophysiological correlates of age-related reduction in working memory capacity, we …