This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …

Mammalian cells remove misfolded proteins using various proteolytic systems, including the
ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and …

Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of
cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy …

Mounting evidence suggests that autophagy is a more selective process than originally
anticipated. The discovery and characterization of autophagic adapters, like p62 and NBR1 …

Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …

Autophagy is essential for neuronal homeostasis, and its dysfunction has been directly
linked to a growing number of neurodegenerative disorders. The reasons behind …

Autophagy delivers cytoplasmic material and organelles to lysosomes for degradation. The
formation of autophagosomes is controlled by a specific set of autophagy genes called atg …

Cytoplasmic α-synuclein (α-syn) aggregates, referred to as Lewy bodies, are pathological
hallmarks of a number of neurodegenerative diseases, most notably Parkinson disease …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Tauopathies are neurodegenerative diseases characterized by the pathological
accumulation of microtubule-associated protein tau (MAPT) in the form of neurofibrillary …