Lack of access to quality diagnostics remains a major contributor to health burden in
resource-limited settings. It has been more than 10 years since ASSURED (affordable …

Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. It is estimated that
25% of the world's population are infected with Mycobacterium tuberculosis, with a 5–10 …

Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid,
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …

Objectives: Tuberculosis (TB) is estimated to be the leading cause of HIV-related deaths
globally. However, since HIV-associated TB frequently remains unascertained, we …

Nearly 40 years have elapsed since the invention of the PCR, with its extremely sensitive
and specific ability to detect nucleic acids via in vitro enzyme-mediated amplification. In turn …

Background Current diagnostics for HIV-associated tuberculosis are suboptimal, with
missed diagnoses contributing to high hospital mortality and approximately 374 000 annual …

Tuberculosis (TB) is the most common cause of death from infectious disease worldwide. A
substantial proportion of patients presenting with extrapulmonary TB have urogenital TB (UG …

Background Although the evidence base regarding the use of the Xpert MTB/RIF assay for
diagnosis of pulmonary tuberculosis (TB) when testing respiratory samples is well …

Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …

During the last decade, remarkable progress has been made in the diagnostics of
pulmonary tuberculosis; however, diagnostic challenges in extra-pulmonary tuberculosis …