Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release
into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease …

Alzheimer's disease is characterized by accumulation of amyloid plaques and tau
aggregates in several cortical brain regions. Tau phosphorylation causes formation of …

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …

Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
function deficits. There are two major pathological hallmarks that contribute to the …

Tau is the major microtubule associated protein (MAP) of a mature neuron. The other two
neuronal MAPs are MAP1 and MAP2. An established function of MAPs is their interaction …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …

Alzheimer disease (AD) and related tauopathies are histopathologically characterized by a
specific type of slow and progressive neurodegeneration, which involves the abnormal …

Prosthetic devices that are controlled by intracortical electrodes recording one's' thoughts'
are a reality today, and no longer merely in the realm of science fiction. However …