Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …

Despite the high prevalence of the LOXL1 variants in the general population, a much lower
proportion of the population develops PEX, suggesting that in addition to LOXL1, other …

The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal
organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial …

Objective To identify geographic and climatic risk factors associated with exfoliation
syndrome (ES). Methods A retrospective study of 626 901 eye care recipients, dating from …

Proteostasis refers to all the processes that maintain the correct expression level, location,
folding and turnover of proteins, essential to organismal survival. Both inside cells and in …

Pseudoexfoliation (PEX) syndrome, one of the most common causes of glaucoma,
represents a complex, multifactorial, late-onset disease of worldwide significance. The …

Purpose.: Pseudoexfoliation (PEX) syndrome/glaucoma is a complex, late-onset disorder of
the elastic fiber system. Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) …

Exfoliation syndrome (XFS) is an age-related systemic disease that affects the extracellular
matrix. It increases the risk of glaucoma (exfoliation glaucoma, XFG) and susceptibility to …

Abstract Lysyl Oxidase Like 1 (LOXL1) is a gene that encodes for the LOXL1 enzyme. This
enzyme is required for elastin biogenesis and collagen cross-linking, polymerising …

Pseudoexfoliation syndrome (PEXS) is a systemic disease caused by defects in the
extracellular matrix (ECM) remodelling process leading to the chronic deposition of …