Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Cathepsin S is a member of the cysteine cathepsin protease family. It is a lysosomal
protease which can promote degradation of damaged or unwanted proteins in the endo …

Macrophages are the first encounters of invading bacteria and are responsible for engulfing
and digesting pathogens through phagocytosis leading to initiation of the innate …

MicroRNAs (miRNAs) are small non-coding highly conserved RNA molecules that can act
as master regulators of gene expression in a sequence-specific manner either by translation …

Rationale: Cathepsin S (CTSS) activity is increased in bronchoalveolar lavage (BAL) fluid
from patients with cystic fibrosis (CF). This activity contributes to lung inflammation via …

Lung antimicrobial proteins and peptides (AMPs) are major sentinels of innate immunity by
preventing microbial colonization and infection. Nevertheless bactericidal activity of AMPs …

Cigarette smoking has marked effects on lung tissue, including induction of oxidative stress,
inflammatory cell recruitment, and a protease/antiprotease imbalance. These effects …

Lung matrix homeostasis partly depends on the fine regulation of proteolytic activities. We
examined the expression of human cysteine cathepsins (Cats) and their relative contribution …

Background. Chronic obstructive pulmonary disease (COPD) is an irreversible disease
mainly caused by smoking. COPD is characterized by emphysema and chronic bronchitis …

Besides their primary involvement in the recycling and degradation of proteins in endo-
lysosomal compartments and also in specialized biological functions, cysteine cathepsins …