Innovative drug delivery strategies for targeting glioblastoma: overcoming the challenges of the tumor microenvironment

S Khot, A Krishnaveni, S Gharat, M Momin… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Glioblastoma multiforme (GBM) presents a challenging endeavor in therapeutic
management because of its highly aggressive tumor microenvironment (TME). This complex …

Multiple therapeutic approaches of glioblastoma multiforme: From terminal to therapy

S Kumari, R Gupta, RK Ambasta, P Kumar - Biochimica et Biophysica Acta …, 2023 - Elsevier
Glioblastoma multiforme (GBM) is an aggressive brain cancer showing poor prognosis.
Currently, treatment methods of GBM are limited with adverse outcomes and low survival …

[HTML][HTML] Recent advances in liposomes and peptide-based therapeutics for glioblastoma treatment

MA Jourdain, J Eyer - Journal of Controlled Release, 2024 - Elsevier
In the context of glioblastoma treatment, the penetration of drugs is drastically limited by the
blood-brain-barrier (BBB). Emerging therapies have focused on the field of therapeutic …

Advancements in Nanocarrier-Mediated Sunitinib Delivery: Addressing Obstacles and Revealing its Therapeutic Promise in Oncological Treatment

MJ Javid-Naderi, Z Abbasi, S Fathi-karkan… - Journal of Drug Delivery …, 2024 - Elsevier
Sunitinib, a versatile receptor tyrosine kinase inhibitor, shows significant clinical
effectiveness against various cancers. However, its therapeutic use is limited by non-specific …

Review of recent preclinical and clinical research on ligand-targeted liposomes as delivery systems in triple negative breast cancer therapy

M Hajimolaali, FA Dorkoosh… - Journal of Liposome …, 2024 - Taylor & Francis
Triple-negative breast Cancer (TNBC) is one of the deadliest types, making up about 20% of
all breast cancers. Chemotherapy is the traditional manner of progressed TNBC treatment; …

Intranasal delivery of sunitinib: A new therapeutic approach for targeting angiogenesis of glioblastoma

E Seidkhani, F Moradi, A Rustamzadeh… - Toxicology and Applied …, 2023 - Elsevier
Glioblastoma multiforme (GBM) is one of the most vascular among solid tumors, and despite
the use of multimodal therapies, the survival of these patients is poor. In order to target …

Unlocking nature's arsenal: Nanotechnology for targeted delivery of venom toxins in cancer therapy

PS Chary, S Shaikh, N Rajana, V Bhavana… - Biomaterials …, 2024 - Elsevier
Aim The aim of the present review is to shed light on the nanotechnological approaches
adopted to overcome the shortcomings associated with the delivery of venom peptides …

Angiogenic lipid-based drug delivery system (PhytoSolve) for treatment of a thin endometrium in animal model

L Haghighi, M Ajdary, A Govahi, S Chaichian… - Tissue and Cell, 2024 - Elsevier
Impaired vascular growth resulting from reduced vascular endothelial growth factor (VEGF)
in the epithelial tissue of the glands is a primary cause of thin endometrium. Inducing …

Indole Antitumor Agents in Nanotechnology Formulations: An Overview

E Russo, C Grondona, C Brullo, A Spallarossa, C Villa… - Pharmaceutics, 2023 - mdpi.com
The indole heterocycle represents one of the most important scaffolds in medicinal chemistry
and is shared among a number of drugs clinically used in different therapeutic areas. Due to …

[PDF][PDF] Indole Antitumor Agents in Nanotechnology Formulations: An Overview. Pharmaceutics 2023, 15, 1815

E Russo, C Grondona, C Brullo, A Spallarossa, C Villa… - 2023 - academia.edu
The indole heterocycle represents one of the most important scaffolds in medicinal chemistry
and is shared among a number of drugs clinically used in different therapeutic areas. Due to …