Daptomycin is a lipopeptide antimicrobial with in vitro bactericidal activity against Gram-
positive bacteria that was first approved for clinical use in 2004 in the United States. Since …

Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients
for various indications recent years. It is still intricate for clinicians to decide a suitable …

Objective: To summarize current antibiotic dosing recommendations in critically ill patients
receiving intermittent hemodialysis (IHD), prolonged intermittent renal replacement therapy …

Initial adequate anti-infective therapy is associated with significantly improved clinical
outcomes for patients with severe infections. However, in critically ill patients, several …

ABSTRACT A careful management of antimicrobials is essential in the critically ill with acute
kidney injury, especially if renal replacement therapy is required. Acute kidney injury may …

Improving antibiotic dosing in special situations in the ICU... : Current Opinion in Critical Care
Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy …

Surprisingly, misinterpretation of the influence of hypoalbuminemia on pharmacokinetics
and the clinical effects of drugs seems to be a current problem, even though …

A common cause of acute kidney injury (AKI) is sepsis, which makes appropriate dosing of
antibiotics in these patients essential. Drug dosing in critically ill patients with AKI, however …

Determining appropriate antibiotic dosing for critically ill patients receiving renal
replacement therapy (RRT) is complex. Worldwide unstandardized and heterogeneous …

Increasing evidence suggests that antibiotic dosing in critically ill patients with acute kidney
injury (AKI) often does not achieve pharmacodynamic goals, and the continued high …