Chimeric antigen receptor-engineered NK-92 cells: an off-the-shelf cellular therapeutic for targeted elimination of cancer cells and induction of protective antitumor …

C Zhang, P Oberoi, S Oelsner, A Waldmann… - Frontiers in …, 2017 - frontiersin.org
Significant progress has been made in recent years toward realizing the potential of natural
killer (NK) cells for cancer immunotherapy. NK cells can respond rapidly to transformed and …

[HTML][HTML] Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson's disease

E Kip, LC Parr-Brownlie - Ageing Research Reviews, 2022 - Elsevier
Parkinson's disease (PD) is the second most common age-associated neurodegenerative
disorder and is characterised by progressive loss of dopamine neurons in the substantia …

Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma

O Melaiu, M Chierici, V Lucarini, G Jurman… - Nature …, 2020 - nature.com
Tumor-infiltrating lymphocytes play an essential role in improving clinical outcome of
neuroblastoma (NB) patients, but their relationship with other tumor-infiltrating immune cells …

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

CS Brandt, M Baratin, EC Yi, J Kennedy… - Journal of Experimental …, 2009 - rupress.org
Cancer development is often associated with the lack of specific and efficient recognition of
tumor cells by the immune system. Natural killer (NK) cells are lymphocytes of the innate …

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

MP Longhi, C Trumpfheller, J Idoyaga… - Journal of Experimental …, 2009 - rupress.org
Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:
polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4+ T cell responses to …

A basic overview of multiple sclerosis immunopathology

N Grigoriadis, V Van Pesch - European journal of neurology, 2015 - Wiley Online Library
Multiple sclerosis (MS) is a multi‐component disease characterized by inflammation,
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …

Natural-killer cells and dendritic cells:“l'union fait la force”

T Walzer, M Dalod, SH Robbins, L Zitvogel, E Vivier - Blood, 2005 - ashpublications.org
Several recent publications have focused on the newly described interactions between
natural-killer (NK) cells and dendritic cells (DCs). Activated NK cells induce DC maturation …

[HTML][HTML] The impact of ageing on natural killer cell function and potential consequences for health in older adults

J Hazeldine, JM Lord - Ageing research reviews, 2013 - Elsevier
Forming the first line of defence against virally infected and malignant cells, natural killer
(NK) cells are critical effector cells of the innate immune system. With age, significant …

CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets

MK Gleason, JA Ross, ED Warlick… - Blood, The Journal …, 2014 - ashpublications.org
Myelodysplastic syndromes (MDS) are stem cell disorders that can progress to acute
myeloid leukemia. Although hematopoietic cell transplantation can be curative, additional …

The interplay between MicroRNAs and cellular components of tumour microenvironment (TME) on non‐small‐cell lung cancer (NSCLC) progression

SS Lee, YK Cheah - Journal of immunology research, 2019 - Wiley Online Library
Cellular components of the tumour microenvironment (TME) are recognized to regulate the
hallmarks of cancers including tumour proliferation, angiogenesis, invasion, and metastasis …