Recombinant ASF live attenuated virus strains as experimental vaccine candidates
African swine fever (ASF) is causing a pandemic affecting swine in a large geographical
area of the Eastern Hemisphere, from Central Europe to East and Southeast Asia, and …
area of the Eastern Hemisphere, from Central Europe to East and Southeast Asia, and …
Recent progress on gene-deleted live-attenuated African swine fever virus vaccines
HLX Vu, DS McVey - npj Vaccines, 2024 - nature.com
Abstract African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality
rates approaching 100%. The disease has spread to many swine-producing countries …
rates approaching 100%. The disease has spread to many swine-producing countries …
Deletion of the A137R gene from the pandemic strain of African swine fever virus attenuates the strain and offers protection against the virulent pandemic virus
African swine fever virus (ASFV) is causing a devastating pandemic in domestic and wild
swine within an extended geographical area from Central Europe to East Asia, resulting in …
swine within an extended geographical area from Central Europe to East Asia, resulting in …
African swine fever virus bearing an I226R gene deletion elicits robust immunity in pigs to African swine fever
Y Zhang, J Ke, J Zhang, J Yang, H Yue, X Zhou… - Journal of …, 2021 - Am Soc Microbiol
African swine fever (ASF) is a severe hemorrhagic infectious disease in pigs caused by
African swine fever virus (ASFV), leading to devastating economic losses in epidemic …
African swine fever virus (ASFV), leading to devastating economic losses in epidemic …
Combinational deletions of MGF360-9L and MGF505-7R attenuated highly virulent African swine fever virus and conferred protection against homologous challenge
M Ding, W Dang, H Liu, F Xu, H Huang… - Journal of …, 2022 - Am Soc Microbiol
Multigene family (MGF) gene products are increasingly reported to be implicated in African
swine fever virus (ASFV) virulence and attenuation of host defenses, among which the …
swine fever virus (ASFV) virulence and attenuation of host defenses, among which the …
Evaluation of the deletion of MGF110-5L-6L on swine virulence from the pandemic strain of African swine fever virus and use as a DIVA marker in vaccine candidate …
African swine fever virus (ASFV) is responsible for an ongoing pandemic that is affecting
central Europe, Asia, and recently the Dominican Republic, the first report of the disease in …
central Europe, Asia, and recently the Dominican Republic, the first report of the disease in …
Differential effect of deleting members of African swine fever virus multigene families 360 and 505 from the genotype II Georgia 2007/1 isolate on virus replication …
A Rathakrishnan, S Connell, V Petrovan… - Journal of …, 2022 - Am Soc Microbiol
African swine fever virus multigene family (MGF) 360 and 505 genes have roles in
suppressing the type I interferon response and in virulence in pigs. The role of the individual …
suppressing the type I interferon response and in virulence in pigs. The role of the individual …
The 2022 Outbreaks of African Swine Fever Virus Demonstrate the First Report of Genotype II in Ghana
E Spinard, A Rai, J Osei-Bonsu, V O'Donnell… - Viruses, 2023 - mdpi.com
African swine fever (ASF) is a lethal disease of domestic pigs that has been causing
outbreaks for over a century in Africa ever since its first discovery in 1921. Since 1957, there …
outbreaks for over a century in Africa ever since its first discovery in 1921. Since 1957, there …
Deletion of African swine fever virus histone-like protein, A104R from the Georgia isolate drastically reduces virus virulence in domestic pigs
E Ramirez-Medina, EA Vuono, S Pruitt, A Rai… - Viruses, 2022 - mdpi.com
African swine fever virus (ASFV) is the etiological agent of a frequently lethal disease, ASF,
affecting domestic and wild swine. Currently, ASF is causing a pandemic affecting pig …
affecting domestic and wild swine. Currently, ASF is causing a pandemic affecting pig …
Deletion of the H240R Gene in African Swine Fever Virus Partially Reduces Virus Virulence in Swine
E Ramirez-Medina, A Rai, N Espinoza, A Valladares… - Viruses, 2023 - mdpi.com
African swine fever (ASF) is a highly contagious disease that affects wild and domestic
swine. Currently, the disease is present as a pandemic affecting pork production in Eurasia …
swine. Currently, the disease is present as a pandemic affecting pork production in Eurasia …