Mechanisms of Polycomb group protein function in cancer
V Parreno, AM Martinez, G Cavalli - Cell research, 2022 - nature.com
Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …
Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation
MM Mitchener, TW Muir - Molecular cell, 2022 - cell.com
Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now
appreciated that somatic missense mutations in histones, the packaging agents of genomic …
appreciated that somatic missense mutations in histones, the packaging agents of genomic …
Failure of human rhombic lip differentiation underlies medulloblastoma formation
Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4 …
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4 …
Single substitution in H3. 3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Germline histone H3. 3 amino acid substitutions, including H3. 3G34R/V, cause severe
neurodevelopmental syndromes. To understand how these mutations impact brain …
neurodevelopmental syndromes. To understand how these mutations impact brain …
Regional identity of human neural stem cells determines oncogenic responses to histone H3. 3 mutants
RB Bressan, B Southgate, KM Ferguson, C Blin… - Cell Stem Cell, 2021 - cell.com
Point mutations within the histone H3. 3 are frequent in aggressive childhood brain tumors
known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in …
known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in …
Histone mutations in cancer
KN Espinoza Pereira, J Shan, JD Licht… - Biochemical Society …, 2023 - portlandpress.com
Genes encoding histone proteins are recurrently mutated in tumor samples, and these
mutations may impact nucleosome stability, histone post-translational modification, or …
mutations may impact nucleosome stability, histone post-translational modification, or …
Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma
R Siddaway, L Canty, S Pajovic, S Milos, E Coyaud… - Acta …, 2022 - Springer
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers
of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of …
of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of …
Updated concepts in treatment of giant cell tumor of bone
L van der Heijden, A Lipplaa… - Current opinion in …, 2022 - journals.lww.com
Neoadjuvant denosumab is highly effective for advanced GCTB, and a short-course is
advised to facilitate surgery, whereas increased recurrence rates remain of concern …
advised to facilitate surgery, whereas increased recurrence rates remain of concern …
Oncohistones: a roadmap to stalled development
Since the discovery of recurrent mutations in histone H3 variants in paediatric brain tumours,
so‐called 'oncohistones' have been identified in various cancers. While their mechanism of …
so‐called 'oncohistones' have been identified in various cancers. While their mechanism of …
Epigenetically defined therapeutic targeting in H3. 3G34R/V high-grade gliomas
High-grade gliomas with arginine or valine substitutions of the histone H3. 3 glycine-34
residue (H3. 3G34R/V) carry a dismal prognosis, and current treatments, including …
residue (H3. 3G34R/V) carry a dismal prognosis, and current treatments, including …