Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …

Caspases are proteolytic enzymes that belong to the cysteine protease family and play a
crucial role in homeostasis and programmed cell death. Caspases have been broadly …

Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

It is now clear that human neoplasms form, progress, and respond to therapy in the context
of an intimate crosstalk with the host immune system. In particular, accumulating evidence …

An innovative approach for cardiac regeneration following injury is to induce endogenous
cardiomyocyte (CM) cell cycle re-entry. In the present study, CMs from adult rat hearts were …

The present review aims at reviewing the role of metformin in the treatment of endometrial
cancer (EC). According to the literature, excessive estrogen levels and insulin resistance are …

Background Apoptosis is a genetically programmed form of cell death, of which caspases
are the central components. Methods By tissue microarray of 229 cases of oral squamous …

Caspases are important regulators and executioners in the apoptosis pathways and play
crucial roles in carcinogenesis. We tested the hypothesis that functional variants of CASP …

The incidence of esophageal adenocarcinoma (EA) has been increasing rapidly, particularly
among white males, over the past few decades in the USA. However, the etiology of EA and …

Background In vitro studies have demonstrated the role of the BCL-2 family of genes in
endometrial carcinogenesis. The role of genetic variants in BCL-2 genes and their …